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Acid Phosphatase (ACP), Serum

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Serum acid phosphatase measurement is used to predict relapse after radical prostatectomy for localized prostate cancer in combination with measurement of specific prostate antigen.

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Acid phosphatase (ACP), an enzyme found mainly in the prostate gland, with high concentrations in the sperm. It is found at lower concentrations in the kidneys, liver, spleen, bone marrow, erythrocytes and platelets. Acid phosphatase is used in the diagnosis of advanced metastatic prostate cancer and in monitoring the patient's response to treatment for prostate cancer.

In the past, acid phosphatase was used as a cancer marker for prostate cancer. However, following the discovery of prostate specific antigen (PSA), monitoring of acid phosphatase decreased in popularity. Acid phosphatase is also used to examine vaginal secretions during rape investigations.

Possible Interpretations of Pathological Values
  • Increase: Acute renal failure, bone metastases, breast cancer, cirrhosis, eclampsia, Gaucher disease, haemolytic anemia, hepatitis, hyperparathyroidism, liver tumors, multiple myeloma, obstructive jaundice. Medications: Anabolic steroids, androgens, clofibrate.
  • Decrease: - Medications: Alcohol, fluorine, oxalates, phosphates.




Important Note

Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".

Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.

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